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Sample preparation for metabolomics analysis For metabolomic analysis, bFLS were stimulated with 100 ng/ml bovine TNF- (bTNF-

Animal and tissue Adult male SD rats, weight 250300 g were purchased from National Laboratory Animal Center (Taipei, Taiwan, ROC)

Animal model studies have suggested that GLP-1RAs may cause pancreatitis and exocrine dysplasia, but in the large RCTs and a meta-analysis, GLP-1RAs did not increase the risk of pancreatitis or pancreatic cancer [82,83]